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吴永宁

 日期:2016年09月14日  人气指数:3905

吴永宁.jpg

吴永宁

国家食品安全风险评估中心技术总师,重点实验室主任,WHO食品污染监测合作中心(中国)主任

博士,研究员、博士生导师

研究领域:食品化学与污染监控

教育背景及工作经历

1983毕业于南京医科大学(原南京医学院)获公共卫生学士,1986和1997年毕业于原中国预防医学科学院分别获得营养与食品卫生硕士和博士学位,并在WHO国际癌症研究中心(IARC)UICC学者和英国医学研究会毒理学部(MRC Toxicology Unit)作为皇家学会学者。紧密结合我国食品污染物风险评估与监管的需要,开展中国总膳食研究及其机体负荷监控技术研究,发展化学污染物暴露组表征与评估技术。针对持久性有机污染物 (二噁英、多氯联苯、溴代阻燃剂、全氟有机物) 和氯丙醇、丙烯酰胺、克伦特罗等食品污染与非法添加热点问题开展检测技术研究,多次参加并组织国内实验室参加二噁英等国际比对以优秀成绩通过,使我国食品重要有机污染物的痕量与超痕量检测获得国际认可,在此基础上建立了从筛选、定量到确证的一套国家标准。特别是利用暴露评估研究,制定了食品污染和真菌毒素限量及其配套检验方法食品安全国家标准,并牵头制定大米无机砷限量国际食品法典标准。

2007年入选国家新世纪百千万人才工程,2010年享受国务院特殊津贴,2011年获吴阶平-保罗.杨森医学药物奖(公共卫生),2012年获卫生部有突出贡献中青年科学家。

主要成果

国家科技进步奖二等奖(2006),中国分析测试协会科技进步特等奖(2014),中国食品科学技术学会一等奖(2014),中国标准创新贡献奖一等奖(2007),华夏医学科技奖一等奖(2011),中华医学科技奖二等奖(2012和2005),北京市科技奖二等奖(2011),中国石油与化学工业行业协会科技进步奖二等奖(2011),福建省科技奖二等奖(2010)等。主编专著8部,发表SCI论文百余篇,h指数 30。

主要兼职

1)FAO/WHO食品添加剂联合专家委员会(JECFA)

2)美国药典委员会食品原料专家委员会(USP Food Chemical Codex)兼联合标准物质、故意掺假专家

3)国务院食品安全委员会专家委员会委员

4)食品安全国家标准审评委员会污染物委员会主任

5)国家食品安全风险评估委员会委员

6)国家标准化委员会委员

7)中华医学会公共卫生分会副主任

8)中国化学会环境化学分会副主任

9)中国毒理学会分析毒理委员会主任

10)中国生态学会生态健康与人类生态委员会主任

11)Food Additives and Contaminants编委

12)Biomedical and Environmental Science编委

13)食品安全质量检验学报主编

2014-2016年发表的论文论著:

1.Chen D, Zhao Y, Miao H, Wu Y. A novelcation exchange polymer as a reversed-dispersive solid phase extraction sorbentfor the rapid determination of rhodamine B residue in chili powder and chilioil. J Chromatogr A. 2014; 1374:268-72.

2.FangM, Lei F, Zhou J, Wu Y-N, Gong Z-Y. Rapid, simple and selective determinationof 2,4-dinitrophenol by molecularly imprinted spin column extraction coupledwith fluorescence detection. Chin Chem Lett. 2014; 25(11):1492-4.

3.GaoY, Lu Y, Huang S, Gao L, Liang X, Wu Y, Wang J, Huang Q, Tang L, Wang G, YangF, Hu S, Chen Z, Wang P, Jiang Q, Huang R, Xu Y, Yang X, Ong CN. Identifyingearly urinary metabolic changes with long-term environmental exposure tocadmium by mass-spectrometry-based metabolomics. Environ Sci Technol. 2014;48(11):6409-18.

4.GaoYX, Zhang H, Yu X, He JL, Shang X, Li X, Zhao Y, Wu Y. Risk and benefitassessment of potential neurodevelopmental effect resulting from consumption ofmarine fish from a coastal archipelago in China. J Agric Food Chem. 2014;62(22):5207-13.

5.HuangF, Wen S, Li J, Zhong Y, Zhao Y, Wu Y. The human body burden of polybrominateddiphenyl ethers and their relationships with thyroid hormones in the generalpopulation in Northern China. Sci Total Environ. 2014; 466-467:609-15.

6.JinY, Liu P, Sun J, Wang C, Min J, Zhang Y, Wang S, Wu Y. Dietary exposure andrisk assessment to lead of the population of Jiangsu province, China. FoodAddit Contam A. 2014; 31(7):1187-95.

7.JinY, Liu P, Wu Y, Min J, Wang C, Sun J, Zhang Y. A systematic review on food leadconcentration and dietary lead exposure in China. Chin Med J (Engl). 2014;127(15):2844-9.

8.LiuX, Huang da W, Wu KJ, Wu YN, Jia XW, Gong ZY. An evaluation of genotoxicity andcytotoxicity of melamine in combination with cyanuric acid at three massratios. Biomed Environ Sci. 2014; 27(8):641-5.

9.ShaoY, Wang J, Chen X, Wu Y. The consolidation of food contaminants standards inChina. Food Control. 2014; 43:213-6.

10.WangLC, Yu YQ, Fang M, Zhan CG, Pan HY, Wu YN, Gong ZY. Antioxidant andantigenotoxic activity of bioactive extracts from corn tassel. J Huazhong UnivSci Technolog Med Sci. 2014; 34(1):131-6.

11.WangS, Lin LM, Wu YN, Fang M, Yu YQ, Zhou J, Gong ZY. Angiotensin I ConvertingEnzyme (ACE) inhibitory activity and antihypertensive effects of grass carppeptides. Food Sci Biotechnol. 2014; 23(5):1661-6.

12.WuK, Liu X, Fang M, Wu Y, Gong Z. Zearalenone induces oxidative damage involvingKeap1/Nrf2/HO-1 pathway in hepatic L02 cells. Mol Cel Toxicol. 2014;10(4):451-7.

13.WuY, Wen J, Ma Y, Ma X, Chen Y. Epidemiology of foodborne disease outbreakscaused by Vibrio parahaemolyticus,China, 2003-2008. Food Control. 2014; 46:197-202.

14.YangY, Lu L, Zhang J, Yang Y, Wu Y, Shao B. Simultaneous determination of sevenbisphenols in environmental water and solid samples by liquidchromatography-electrospray tandem mass spectrometry. J Chromatogr A. 2014;1328:26-34.

15.ZhangH, Wang D, Zhang J, Shang X, Zhao Y, Wu Y. Total mercury in milled rice andbrown rice from China and health risk evaluation. Food Addit Contam Part BSurveill. 2014; 7(2):141-6.

16.ZhongQD, Li GH, Wang DB, Shao Y, Li JG, Xiong ZH, Wu YN. Exposure assessment toochratoxin A in Chinese wine. J Agric Food Chem. 2014; 62(35):8908-13.

17.ZhuP, Fan S, Zou JH, Miao H, Li JG, Zhang GW, Wu YN. Application of gaschromatography-mass spectrometry in analyzing pharmacokinetics and distributionof deltamethrin in miniature pig tissues. Biomed Environ Sci. 2014;27(6):426-35.

18.ZhuP, Miao H, Du J, Zou JH, Zhang GW, Zhao YF, Wu YN. Organochlorine pesticidesand pyrethroids in Chinese tea by screening and confirmatory detection usingGC-NCI-MS and GC-MS/MS. J Agric Food Chem. 2014; 62(29):7092-100.

19.BaQ, Li J, Huang C, Li J, Chu R, Wu Y, Wang H. Topological, functional, anddynamic properties of the protein interaction networks rewired bybenzo(a)pyrene. Toxicol Appl Pharmacol. 2015; 283(2):83-91.

20.BaQ, Li J, Huang C, Qiu H, Chu R, Zhang W, Xie D, Wu Y, Wang H. Effects ofBenzo[a]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis,Metastasis, and NF-kappaB Signaling. Environ Health Perspect. 2015;123(3):246-54.

21.ChenD, Miao H, Zou J, Cao P, Ma N, Zhao Y, Wu Y. Novel dispersive micro-solid-phaseextraction combined with ultrahigh-performance liquidchromatography-high-resolution mass spectrometry to determine morpholineresidues in citrus and apples. J Agric Food Chem. 2015; 63(2):485-92.

22.ChenD, Miao H, Zou J, Miao H, Lu L, Zhao Y, Wu Y. Determination of phthalate estersin liquor by high resolution mass spectrometry. Anal Lett. 2015; 48:739-51.

23.ChenD, Ren Y, Zhong Q, Shao Y, Zhao Y, Wu Y. Ethyl carbamate in alcoholic beveragesfrom China: Levels, dietary intake, and risk assessment. Food Control. 2015.

24.ChenD, Zhang S, Miao H, Zhao Y, Wu Y. Simple and rapid analysis of muscarine inhuman urine using dispersive micro-solid phase extraction and ultra-highperformance liquid chromatography-high resolution mass spectrometry. AnalMethods. 2015; 7:3720-7.

25.ChenD, Zhang Y, Miao H, Zhao Y, Wu Y. Determination of triazine herbicides indrinking water by dispersive micro solid phase extraction withultrahigh-performance liquid chromatography-high-resolution mass spectrometricdetection. J Agric Food Chem. 2015; 63(44):9855-62.

26.ChenD, Zhao Y, Miao H, Wu Y. A novel dispersive micro solid phase extraction usingPCX as the sorbent for the determination of melamine and cyromazine in milk andmilk powder by UHPLC-HRMS/MS. Talanta. 2015; 134:144-52.

27.GaoYX, Zhang HX, Li JG, Zhang L, Yu XW, He JL, Shang XH, Zhao YF, Wu YN. Thebenefit risk assessment of consumption of marine species based on Benefit-RiskAnalysis for Foods (BRAFO)-tiered approach. Biomed Environ Sci. 2015;28(4):243-52.

28.JiangW, Beloglazova NV, Wang Z, Jiang H, Wen K, de Saeger S, Luo P, Wu Y, Shen J.Development of a multiplex flow-through immunoaffinity chromatography test forthe on-site screening of 14 sulfonamide and 13 quinolone residues in milk.Biosens Bioelectron. 2015; 66:124-8.

29.LiH, Chen D, Miao H, Zhao Y, Shen J, Wu Y. Direct determination of fatty acidesters of 3-chloro-1, 2-propanediol in edible vegetable oils by isotopedilution - ultra high performance liquid chromatography - triple quadrupolemass spectrometry. J Chromatogr A. 2015; 1410:99-109.

30.LiX, Xie K, Yue B, Gong Y, Shao Y, Shang X, Wu Y. Inorganic arsenic contaminationof rice from Chinese major rice-producing areas and exposure assessment inChinese population. Sci China Chem. 2015; (12):1-8.

31.NiuY, Zhang J, Duan H, Wu Y, Shao B. Bisphenol A and nonylphenol in foodstuffs:Chinese dietary exposure from the 2007 total diet study and infant health riskfrom formulas. Food Chem. 2015; 167:320-5.

32.SpinkJ, Moyer DC, Park H, Wu Y, Fersht V, Shao B, Hong M, Paek SY, Edelev D.Introducing Food Fraud including translation and interpretation to Russian,Korean, and Chinese languages. Food Chem. 2015; 189:102-7.

33.WangX, Zhang H, Zhang L, Zhong K, Shang X, Zhao Y, Tong Z, Yu X, Li J, Wu Y.Assessment on dioxin-like compounds intake from various marine fish fromZhoushan Fishery, China. Chemosphere. 2015; 118C:163-9.

34.ZhangL, Yin S, Wang X, Li J, Zhao Y, Li X, Shen H, Wu Y. Assessment of dietaryintake of polychlorinated dibenzo-p-dioxinsand dibenzofurans and dioxin-like polychlorinated biphenyls from the ChineseTotal Diet Study in 2011. Chemosphere. 2015; 137:178-84.

35.ZhangYR, Wang P, Liang XX, Tan CS, Tan JB, Wang J, Huang Q, Huang R, Li ZX, Chen WC,Wu SX, Ong CN, Yang XF, Wu YN. Associations between urinary excretion ofcadmium and renal biomarkers in nonsmoking females: a cross-sectional study inrural areas of south China. Int J Environ Res Public Health. 2015; 12(10):11988-2001.

36.ZhouS, Wang D, Zhang C, Zhao Y, Zhao M, Wu Y. A novel interaction mode betweenacrylamide and its specific antibody. J Immunoassay Immunochem. 2015;36(3):295-311.

37.ZhouS, Wang D, Zhao Y, Wu Y. A rapid HPLC method for indirect quantification ofbeta-lactamase activity in milk. J Dairy Sci. 2015; 98(4):2197-204.

38.BaQ, Li M, Chen P, Huang C, Duan X, Lu L, Li J, Chu R, Xie D, Song H, Wu Y, YingH, Jia X, Wang H. Gender-dependent effects of cadmium exposure in early life ongut microbiota and fat accumulation in mice. Environ Health Perspect. 2016.

39.ChenY, Cheng X, Mo F, Huang L, Wu Z, Wu Y, Xu L, Fu F. Ultra-sensitive speciationanalysis of mercury by CE-ICP-MS together with field-amplified sample stackinginjection and dispersive solid-phase extraction. Electrophoresis. 2016;37(7-8):1055-62.

40.ChenY, Yuan B, Xie G, Zhen S, Zhou Y, Shao B, Zhang J, Ji H, Wu Y. Outbreak of HaffDisease caused by consumption of crayfish (Procambarusclarkii), Nanjing, Jiangsu Province, China. Food Control. 2016; 59:690-4.

41.CuiX, Wang J, Qiu N, Wu Y. In vitro toxicological evaluation of ethyl carbamate inhuman HepG2 cells. Toxicol Res. 2016; 54(5):697-702.

42.GaoJ, Zhao Y, Zhu F, Ma Y, Li X, Miao H, Wu Y. Dietary exposure of acrylamide fromthe fifth Chinese Total Diet Study. Food Chem Toxicol. 2016; 87:97-102.

43.HeY, Chen Z, Mo F, Huang L, Xu L, Wu Y, Xue Z, Fu F. Species characteristics oflead in sea foods collected from coastal water of Fujian, Southeastern ofChina. Sci Rep. 2016; 6:33294.

44.HipgraveDB, Chang S, Li X, Wu Y. Salt and sodium intake in China. JAMA. 2016;315(7):703-5.

45.JiangW, Chen Z, Cheng X, Wu W, Wu Y, Xu L, Fu FF. A novel ion imprinted SiO2microsphere for the specific and rapid extraction and pre-concentration of ultra-tracemethyl mercury. RSC Adv. 2016; 6(46):40100-5.

46.LeiF, Li C, Zhou S, Wang D, Zhao Y, Wu Y. Hyphenation of supercritical fluidchromatography with tandem mass spectrometry for fast determination of fouraflatoxins in edible oil. Rapid Commun Mass Spectrom. 2016; 30 Suppl 1:122-7.

47.LiG, Fu H, Chen X, Gong P, Chen G, Xia L, Wang H, You J, Wu Y. Facile andsensitive fluorescence sensing of alkaline phosphatase activity withphotoluminescent carbon dots based on inner filter effect. Anal Chem. 2016;88(5):2720-6.

48.LiG, Kong W, Zhao M, Lu S, Gong P, Chen G, Xia L, Wang H, You J, Wu Y. Afluorescence resonance energy transfer (FRET) based "Turn-On"nanofluorescence sensor using a nitrogen-doped carbon dot-hexagonal cobaltoxyhydroxide nanosheet architecture and application to α-glucosidase inhibitorscreening. Biosens Bioelectron. 2016; 79:728-35.

49.LiuL, Hu Q, Wu H, Xue Y, Cai L, Fang M, Liu Z, Yao P, Wu Y, Gong Z. Protectiverole of n6/n3 PUFA supplementation with varying DHA/EPA ratios againstatherosclerosis in mice. J Nutr Biochem. 2016; 32:171-80.

50.LiuX, Wen S, Li J, Zhang L, Zhao Y, Wu Y. A study on the levels of apolybrominated biphenyl in Chinese human milk samples collected in 2007 and2011. Environ Monit Assess. 2016; 188(9):515.

51.LiuX, Zheng L, Zhang R, Liu G, Xiao S, Qiao X, Wu Y, Gong Z. Toxicologicalevaluation of advanced glycation end product Nε-(carboxymethyl)lysine:Acute and subacute oral toxicity studies. Regul Toxicol Pharmacol. 2016;77:65-74.

52.LiuY, Ran R, Hu C, Cui B, Xu Y, Liu H, Quan S, Li D, Li X, Wu Y, Zhang D, Shi J.The metabolic responses of HepG2 cells to the exposure of mycotoxindeoxynivalenol. World Mycotoxin J. 2016:1-10.

53.LuS, Li G, Lv Z, Qiu N, Kong W, Gong P, Chen G, Xia L, Guo X, You J, Wu Y. Facileand ultrasensitive fluorescence sensor platform for tumor invasive biomakerβ-glucuronidase detection and inhibitor evaluation with carbon quantum dotsbased on inner-filter effect. Biosens Bioelectron. 2016; 85:358-62.

54.QiuN, Wu D, Cui X, Li G, Fan S, Chen D, Zhao Y, Wu Y. Simultaneous determinationof multiple intracellular primary metabolites by ultrahigh performance liquidchromatography coupled with a Q Exactive HF mass spectrometer. Anal Chem. 2016.

55.ShangX, Dong G, Zhang H, Zhang L, Yu X, Li J, Wang X, Yue B, Zhao Y, Wu Y.Polybrominated diphenyl ethers (PBDEs) and indicator polychlorinated biphenyls(PCBs) in various marine fish from Zhoushan fishery, China. Food Control. 2016;67:240-6.

56.ShenH, Guan R, Ding G, Chen Q, Lou X, Chen Z, Zhang L, Xing M, Han J, Wu Y.Polychlorinated dibenzo-p-dioxins/furans(PCDD/Fs) and polychlorinated biphenyls (PCBs) in Zhejiang foods (2006-2015):Market basket and polluted areas. Sci Total Environ. 2016; 574:120-7.

57.ShenH, Starr J, Han J, Zhang L, Lu D, Guan R, Xu X, Wang X, Li J, Li W, Zhang Y, WuY. The bioaccessibility of polychlorinated biphenyls (PCBs) and polychlorinateddibenzo-p-dioxins/furans (PCDD/Fs) incooked plant and animal origin foods. Environ Int. 2016; 94:33-42.

58.ShiZ, Zhang L, Li J, Zhao Y, Sun Z, Zhou X, Wu Y. Novel brominated flameretardants in food composites and human milk from the Chinese Total Diet Studyin 2011: Concentrations and a dietary exposure assessment. Environ Int. 2016;96:82-90.

59.SpinkJ, Fortin ND, Moyer DC, Miao H, Wu Y. Food Fraud prevention: policy, strategy,and Decision-Making - Implementation steps for a government agency or industry.Chimia. 2016; 70(5):320-8.

60.SunJ, Wu Y. Evaluation of dietary exposure to deoxynivalenol (DON) and itsderivatives from cereals in China. Food Control. 2016; 69:90-9.

61.WalshTR, Wu Y-n. China bans on colistin as a feed additive for animals. LancetIinfect Dis. 2016.

62.YangL, Li J, Lai J, Luan H, Cai Z, Wang Y, Zhao Y, Wu Y. Placental transfer ofperfluoroalkyl substances and associations with thyroid hormones: Beijingprenatal exposure study. Sci Rep. 2016; 6:21699.

63.YangL, Wang Z, Shi Y, Li J, Wang Y, Zhao Y, Wu Y, Cai Z. Human placental transferof perfluoroalkyl acid precursors: Levels and profiles in paired maternal andcord serum. Chemosphere. 2016; 144:1631-8.

64.YangWJ, Xi Z, Zeng X, Fang L, Jiang W, Wu Y, Xu LJ, Fu FF. Magnetic bead-based AuNPlabelling combined with inductively coupled plasma mass spectrometry forsensitively and specifically counting cancer cells. J Anal At Spectrom. 2016;31(3):679-85.

65.YinJ, Wang H, Li J, Wu Y, Shao B. Occurrence of synthetic musks in human breastmilk samples from 12 provinces in China. Food Addit Contam A. 2016;33(7):1219-27.

66.ZhangH, Lin L, Zeng X, Ruan Y, Wu Y, Lin M, He Y, Fu F. Magnetic beads-based DNAzymerecognition and AuNPs-based enzymatic catalysis amplification for visualdetection of trace uranyl ion in aqueous environment. Biosens Bioelectron.2016; 78:73-9.

67.ZhangL, Yin S, Li J, Zhao Y, Wu Y. Increase of polychlorinated dibenzo-p-dioxins anddibenzofurans and dioxin-like polychlorinated biphenyls in human milk fromChina in 2007-2011. Int J Hyg Environ Health. 2016; 219(8):843-9.

68.ZhangY, Liu P, Jin Y, Wang C, Min J, Wu Y. Dietary exposure and risk assessment tocadmium of the adult population of Jiangsu province, China: Comparing betweensemi-probabilistic and fully probabilistic approaches. Hum Ecol Risk Assess.2016; 22(1):226-40.

69.ZhangY, Liu P, Wang C, Wu Y. Human health risk assessment of cadmium via dietaryintake by children in Jiangsu Province, China. Environ Geochem Health. 2016;38(1).

70.ZhaoM, Li G, Kong W, Lu S, Xia L, Chen G, Zhao X, Wu Y, You J. Convenient andSensitive HPLC method for determination of nitrosamines in foodstuffs based onpre-column fluorescence labeling. Chromatographia. 2016:1-9.

71.ZhaoM, Li G, Qiu N, Chen G, Xia L, You J, Wu Y. Highly efficient and sensitivescreening of ractopamine in foodstuffs by HPLC-FLD using fluorescent labelingand ultrasonic-assisted dispersive liquid–liquid microextraction. Anal Methods.2016; 8(17):3488-95.

72.ZhaoQ, Wang Y, Wang S, Wang Z, Du XD, Jiang H, Xia X, Shen Z, Ding S, Wu C, Zhou B,Wu Y, Shen J. Prevalence and abundance of florfenicol and linezolid resistancegenes in soils adjacent to swine feedlots. Sci Rep. 2016; 6:32192.

73.ZhuP, Liang XX, Wang P, Wang J, Gao YH, Hu SG, Huang Q, Huang R, Jiang Q, Wu SX,Li ZX, Ling HT, Xu YH, Wu YN, Yang XF. Assessment of dietary cadmium exposure:A cross-sectional study in rural areas of south China. Food Control. 2016;62:284-90.

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